Creobic Double Action Mechanism of Action

Pharmacology: Pharmacodynamics: Mechanism of Action: Creobic DA Cream combines the broad spectrum antifungal activity of clotrimazole with the sustained anti-inflammatory, anti-pruritic and vasoconstrictive actions of betamethasone dipropionate. Clotrimazole appears to act on the fungal cell membrane, causing leakage of cell contents.
Pharmacokinetics: Creobic DA Cream is intended for treatment of skin conditions and is applied topically. There are minimal pharmacokinetic aspects related to bioavailability at the site of action. Clotrimazole penetrates the epidermis after topical administration but there is little, if any, systemic absorption. The extent of percutaneous absorption of topical corticosteroids is determined by many factors, including the vehicle, the integrity of the epidermal barrier, and the use of occlusive dressings. Topical corticosteroids can be absorbed from normal intact skin. Inflammation and / or other disease processes in the skin may increase percutaneous absorption of topical corticosteroids. Occlusive dressings substantially increase the percutaneous absorption of topical corticosteroids. Once absorbed through the skin, the pharmacokinetics of topical corticosteroids are similar to systemically administered corticosteroids. Corticosteroids are bound to plasmaproteins in varying degrees. Corticosteroids are metabolized primarily in the liver and are then excreted by the kidneys. Some of the topical corticosteroids and their metabolites are also excreted into the bile.